CALL FOR PAPERS Cardiovascular and Cerebrovascular Aging–New Mechanisms and Insights Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum
نویسندگان
چکیده
Fábio H. Silva, Carolina Lanaro, Luiz Osório Leiria, Renata Lopes Rodrigues, Ana Paula Davel, Mário A. Claudino, Haroldo A. Toque, and Edson Antunes Department of Pharmacology, Faculty of Medical Sciences and Department of Anatomy, Cellular Biology, Physiology and Biophysics, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; and Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia
منابع مشابه
Nerve-induced Release of Nitric Oxide in Gastrointestinal and Erectile Tissue
[Type abstract text here.] Nerve-induced release of nitric oxide LIST OF PUBLICATIONS The present thesis is based on the following papers, which will be referred to by their Roman numerals. I OLGART, C., HALLÉN, K., WIKLUND, N.P., IVERSEN, H.H. & GUSTAFSSON, L.E. (1998). Blockade of nitrergic neuroeffector transmission in guinea-pig colon by a selective inhibitor of soluble guanylyl cyclase. Ac...
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Endothelial dysfunction, as observed in hypertension and atherosclerosis, is associated with a reduction in the bioavailability of endothelium-derived nitric oxide (NO). We tested the hypothesis that alterations in the soluble guanylyl cyclase (sGC) pathway may also contribute to the pathogenesis of hypertension. Therefore, we investigated the expression and activity of sGC in young (6 weeks) a...
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Type 2 diabetes mellitus (DM2) and obesity are major risk factors for erectile dysfunction (ED). In diabetes, increased oxidative stress leads to decreased nitric oxide (NO) bioavailability, and diabetic patients appear to be less responsive to conventional therapy with phosphodiesterase type 5 inhibitors. We investigated whether the soluble guanylyl cyclase stimulator BAY 41-2272 (5-cyclopropy...
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Nitric oxide (NO) is the principal mediator of penile erection, and PDE-5 inhibitors are the first-line agents used to treat erectile dysfunction (ED). When NO formation or bioavailability is decreased by oxidative stress and PDE-5 inhibitors are no longer effective, a new class of agents called soluble guanylate cyclase (sGC) stimulators like BAY 41-8543 will induce erection. sGC stimulators b...
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